The difference between F_1850-PDAY_CAM5 and F_AMIP_CAM5_CN is that the F_1850-PDAY_CAM5 compset uses complete atmospheric forcing data from observed sources up to the year 2005. Following this period it is a combination of observed sources (SST, sea ice, CO2, CH4, N2O) to present day and IPCC RCP4.5 scenario data. They shoudl be teh same until 2005
Scientifically validated configuration means that we ran an experiment with that configuratoion we have looked at it extensively (and we did all the tuning).If not scientifically validated, the user is responsible to do a simulation and to check the climate is ok (and to do some tuning if needed).